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. 2017 Mar 10;23:1224–1231. doi: 10.12659/MSM.899228

Figure 3.

Figure 3

GPD1L is a direct target of miR-181a. (A) Schematic representation of the sequence alignment of the wild-type GPD1L 3′-UTR indicating the binding sites of the miR-181a and the mutant GPD1L 3′-UTR for pmirGLO-report (WT, wild-type; MUT, mutant). (B) Compared with the negative control group (Mimic-Nc), miR-181a mimics significantly inhibited the reporter luciferase activity of the wild-type GPD1L 3′-UTR (* p<0.05) but not that of the mutant GPD1L 3′-UTR (p>0.05) (means ±SD; n=3). (C) Compared with the inhibitor negative control group, the reporter luciferase activity of the wild-type GPD1L 3′-UTR was significantly increased by miR-181a inhibitor (* p<0.05) compared to the mutant GPD1L 3′-UTR (* p>0.05) (means ±SD; n=3).