Table II.
Univariate and multivariate Cox regression analyses of overall survival and disease-free survival in patients with BC.
| Variables | Univariate analysis
|
Multivariate analysis
|
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | |
| OS | ||||||
| Age (≤50 vs. >50 years) | 1.362 | 1.282–2.530 | 0.533 | |||
| Menopausal status (pre vs. post) | 1.342 | 0.601–2.993 | 0.473 | |||
| Histological subtype (ductal vs. lobular) | 1.087 | 0.932–1.397 | 0.710 | |||
| Tumor size (≤2 vs. >2 cm) | 1.549 | 1.247–1.222 | 0.042 | 2.168 | 0.724–2.854 | 0.068 |
| Grade of ductal cancer (I, II vs. III) | 2.372 | 1.532–3.278 | 0.036 | 2.874 | 1.153–3.238 | 0.057 |
| LN metastasis (negative vs. positive) | 1.114 | 1.034–2.382 | 0.000 | 1.136 | 1.040–1.460 | 0.001 |
| Clinical stage (I, II vs. III, IV) | 2.166 | 1.420–3.218 | 0.009 | 2.039 | 1.027–3.995 | 0.015 |
| ER status (negative vs. positive) | 1.458 | 1.032–2.688 | 0.297 | |||
| PR status (negative vs. positive) | 1.362 | 1.067–2.876 | 0.374 | |||
| HER2 status (negative vs. positive) | 1.299 | 0.998–1.745 | 0.107 | |||
| TMPRSS4 expression (low vs. high) | 1.265 | 1.091–1.777 | 0.015 | 1.289 | 1.098–1.850 | 0.016 |
| DFS | ||||||
| Age (≤50 vs. >50 years) | 1.562 | 1.187–2.623 | 0.624 | |||
| Menopausal status (pre vs. post) | 1.447 | 0.648–3.232 | 0.367 | |||
| Histological subtype (ductal vs. lobular) | 1.396 | 0.993–2.056 | 0.802 | |||
| Tumor size (≤2 vs. >2 cm) | 1.567 | 1.278–1.793 | 0.047 | 2.272 | 0.927–3.568 | 0.073 |
| Grade of ductal cancer (I, II vs. III) | 2.569 | 1.587–2.763 | 0.039 | 2.942 | 1.278–3.524 | 0.066 |
| LN metastasis (negative vs. positive) | 2.054 | 1.029–3.398 | 0.001 | 2.143 | 1.042–3.489 | 0.002 |
| Clinical stage (I, II vs. III, IV) | 3.971 | 1.355–5.637 | 0.012 | 2.873 | 1.964–5.761 | 0.018 |
| ER status (negative vs. positive) | 1.545 | 1.058–2.734 | 0.301 | |||
| PR status (negative vs. positive) | 1.378 | 1.075–2.888 | 0.381 | |||
| HER2 status (negative vs. positive) | 1.282 | 0.989–1.763 | 0.147 | |||
| TMPRSS4 expression (low vs. high) | 1.278 | 1.137–1.821 | 0.018 | 1.355 | 1.185–1.971 | 0.019 |
BC, breast cancer; OS, overall survival; DFS, disease-free survival; HR, hazard ratio; CI, confidence interval; LN, lymph node; ER, estrogen receptor; PR, progesterone receptor; HER2, human epidermal growth factor receptor-2.