Figure 6. Responses of 5-HT and DA neurons to outcomes are differentially modulated by expectations.
(A) Mean (± s.e.m.) response of 5-HT neurons, across mice, to the four USs before (day −1, filled bars) and right after (day 0, open bars) reversal (n = 8 mice, two-way ANOVA with factors mouse and day, the main effect of day F1,764 = 84.36, p<0.001 for large reward, F1,748 = 3.49, p=0.062 for small reward, F1,756 = 38.17, p<0.001 for neutral, F1,766 = 2.79, p=0.095 for air puff). (B) Same as (A) for midbrain DA neurons (n = 3 mice, F1,249 = 67.9, p<0.001 for large reward, F1,277 = 8.49, p=0.004 for small reward, F1,278 = 10.95, p=0.001 for neutral, F1,250 = 12.74, p<0.001 for air puff. **p<0.01, ***p<0.001.