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. 2017 Jan 10;65(4):1278–1292. doi: 10.1002/hep.28947

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© 2016 by the American Association for the Study of Liver Diseases

This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

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Viral binding and replication in cholangiocytes treated with TRTRVSRLY as a function of rotavirus strain. Mouse cholangiocytes were pretreated with 1 mM synthetic peptide TRTRVSRLY followed by infection with RRV, TUCH, Ro1845, or GRV. (A) Viral binding revealed significant inhibition of binding only in strains that induce murine biliary atresia (RRV and GRV). DGEA and GHRP are positive and negative controls, respectively. (B) A significant reduction in viral yield in RRV and GRV was measured, with no decrease in replication for TUCH or Ro1845. *P < 0.05 versus serum‐free media.