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. 2017 Jan 10;65(4):1278–1292. doi: 10.1002/hep.28947

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© 2016 by the American Association for the Study of Liver Diseases

This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

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The SRL portion of TRTRVSRLY has an effect on viral binding and replication. (A, B) Mouse cholangiocytes pretreated with TRTRSVRLY or synthetic peptides with altered aa at positions 440 (T→M) or 446 (R→G). Altering aa 440 had a similar effect as TRTRVSRLY while a peptide containing an altered aa 446 could not inhibit RRV binding or replication. (C, D) Cholangiocytes pretreated with 1 mM of synthetic peptides with single aa changes from VSRLY. Peptides conserving the SRL portion maintained the peptide's ability to block RRV binding and replication. Peptides with an altered single aa between 445 and 447 lost the ability to block RRV binding and replication. *P < 0.05 versus serum‐free media.