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. 2017 Jan 10;65(4):1278–1292. doi: 10.1002/hep.28947

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© 2016 by the American Association for the Study of Liver Diseases

This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

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The role of Hsc70 in RRV binding and replication. (A, B) Hsc70 siRNA‐transfected mouse cholangiocytes treated with 1 mM TRTRVSRLY were unable to inhibit RRV binding or replication, whereas DGEA displayed significant inhibition versus serum‐free media in all treatments. (C) Cholangiocytes pretreated with synthetic 1 mM TRTRVSRLY, FSG, and KID were infected with RRV. A significant decrease in viral binding with TRTRVSRLY was seen, with no change in binding with FSG or KID. (D) Viral replication assays with synthetic peptides revealed an inhibition of viral replication in cholangiocytes treated with TRTRVSRLY, FSG, and KID. *P < 0.05 versus serum‐free media.