FIGURE 7.

Combined CR2-Crry and CsA therapy reduces splenic Tc1 cell populations. Flow cytometric analysis of splenocytes for Tc1 cells CD3⁺CD8⁺ CXCR3⁺ (A) and CD3⁺CD4⁺CXCR3⁺ (B) demonstrate a significant reduction in overall number of CD8⁺ CXCR3⁺ cells in the combined therapy group, as compared with control and single therapy CR2-Crry and CsA groups. CD4⁺CXCR3⁺ T cells were significantly reduced in the combined group, as compared with Tx control. Although there was an overall trend to reduced total numbers between combined and CsA alone groups, this did not reach statistical significance. (^# Tx Control vs CR2-Crry + CsA, p < 0.02, *Tx Controls vs CsA p < 0.03, **CsA vs CR2-Crry + CsA, p < 0.04. n = 3 in each group).