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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: J Immunol. 2017 Feb 22;198(7):2989–2999. doi: 10.4049/jimmunol.1602057

Figure 7. Inhibition of C5aR1 signaling in MDSCs favors Th1 and Th17 responses.

Figure 7

Percentage of CD4+ T cells producing (A) IFN-γ, *P=0.0203 or (B) IL-4, *P=0.0174 or (C) IL-17, *P=0.0296; stimulated with CD3/CD28, and co-cultured in the absence (C5aRA in vitro −) or the presence (C5aRA in vitro +) of C5aR antagonist with MDSCs from tumor-bearing mice injected with PBS (C5aRA in vivo −) or C5aR antagonist (C5aRA in vivo +). All statistics by One-Way ANOVA. Each symbol represents an individual mouse. Horizontal lines represent mean + S.E.M. Data are representative of one experiment with n=5.