Table 1.
Cohort Inclusion and Exclusion Criteria (Summarized from Jetté et al.8)
| Inclusion Criteria | Smoker | Nonsmoker | GERD | LPR | Normal |
|---|---|---|---|---|---|
| Age (years) | 18–65 | 18–65 | 18–65 | 18–65 | 18–65 |
| Acid exposure time | -- | -- | >4.0% | -- | <4.0% |
| DeMeester score | -- | -- | >14.7 | -- | <14.7 |
| Bolus (combination of gas and liquid reflux) exposure time | -- | -- | >1.4% | -- | <1.4% |
| Proximal reflux events | -- | -- | -- | >31 | <31 |
| Smoking | ≥5 cigarettes per day for ≥ 1 year | None in previous year | -- | -- | -- |
| Exclusion Criteria | |||||
| Past Medical History: radiation therapy to head and neck within 5 years, chronic sinusitis or rhinitis within past year, acute traumatic event to larynx in last year, malignancy within past 5 years, infectious laryngitis in past 3 months, substance or alcohol abuse | |||||
| Past Surgical History: Lung or gastroesophageal surgery, tracheostomy, laryngeal or tracheal surgery | |||||
| Medications: diazepam, phenytoin, mephenytoin, warfarin, anticholinergics, antineoplastics, prostaglandin analogs, H2-receptor antagonists, steroids (inhaled, oral, intravenous), promotility drugs, sucralfate, theophylline or other investigational compound in previous 60 days, PPI or H2 blockers in past year | |||||
| Pregnancy or lactation | |||||