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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Biotechnol Bioeng. 2016 Dec 27;114(5):1006–1015. doi: 10.1002/bit.26237

Figure 1.

Figure 1

Venn diagram of difficult-to-remove HCP impurities and the mechanism by which they challenge clearance in biopharmaceutical manufacturing. Diagram not drawn to scale.