Fig. 1.

Growth rates and grip strength in mice. (a) Female Zmpste24^–/– Lmna^+/– mice (n = 6) exhibit normal growth, indistinguishable from wild-type mice (n = 5). Similar results were obtained with male mice (data not shown). (b) Muscle strength in 3- to 4-week old and 16- to 17-week-old female wild-type (Lmna^+/–, n = 7), Zmpste24^–/– (n = 5), and Zmpste24^–/–Lmna^+/– mice (n = 9), as judged by the length of time that they were able to hang on to an upside-down grid (1) (grip time; P < 0.001). Similar results were observed for male mice. Differences became statistically significant at 8 weeks of age.