Fig. 3.

Motor coordination, muscle strength, and glycaemia of sixteen 6 month-old mice after 5 month of PIO treatment.

(A) Individualized mice ranked according their motor coordination (Rotarod; upper boxes), their forelimb muscle strength (Grip test; intermediate boxes) or glycaemia (lower boxes). (B) 6 month-old Hq mice ranged according their glycaemia and their grip test performance, untreated (left panel; black circles) or 2 months PIO-treated (right panel; green circles). Numbers on the left panel refer to mouse numbering as in (A). For the sake of comparison, the mean ± 1 SD of 6 month-old untreated WT mice is indicated. Mouse performance determination and statistical tests as described under Materials and Methods.