Fig. 2.

Differential distribution of smoking measures between MethylMix subtypes. Distribution of a) smoking status categories (Pearson's chi-squared test), b) smoking mutation signature rates (overall number of G > T and C > A transversions per individual) (Wilcoxon rank sum test, p-values are shown for C > A and G > T mutations signatures separately), c) copy number aberration rate (Wilcoxon rank sum test) and d) mean expression of xenobiotic metabolism genes (Wilcoxon rank sum test), between MethylMix subtypes. p-Values indicate significance of the differences in smoking variables between the CIMP-Atypical subtype (green) and each other subtype separately. *p < 0.05, **p < 0.01, ***p < 0.001.