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. 2017 Mar 1;17:223–236. doi: 10.1016/j.ebiom.2017.02.025

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© 2017 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 3 — Different aberrant DNA methylation profiles associated with MethylMix subtypes. Variation in the mean number of a) hypermethylated and b) hypomethylated MethylMix genes per patient, between MethylMix subtypes, with a significantly higher number of hypermethylated genes, and lower number of hypomethylated genes in the CIMP-Atypical subtype (green) compared with each other subtype (Wilcoxon rank sum test). c) The proportion of CpG sites in hypermethylated genes that were within CpG islands was highest within the NSD1-Smoking (olive) and CIMP-Atypical (green) subtypes, while the number of hypomethylated CpG sites within CpG islands was highest within the HPV + subtype (blue). ***p < 0.001.