Table 2.
Live births published in peer-reviewed papers after frozen-thawed ovarian tissue transplantations
| Child number | Reference number | Diagnosis | Age at cryopreservation | Sign of menopause before transplantation (FSH; LH; AMH)a | Time from transplantation to pregnancy (months) | Pregnancy | Gestational age (weeks) | Gender | Birth weight | Pregnancy complications | Delivery mode |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 18 | Hodgkin lymphoma | 25 | Yes (Am; FSH 91; LH 85) | 11 | NC | 39 | F | 3720 | NS | NS |
| 2 | 19 | Non-Hodgkin lymphoma | 28 | Yes (Am; FSH 40; LH 104; AMH <dL) | 9 | IVF | 38 | F | 3000 | None | CS |
| 3 + 4 | 20, 21 | Hodgkin lymphoma | 24 | Yes (Am; FSH 87) | 5/33 | NC/NC | 41/39 | F/F | 3130/2870 | None/NS | NS/NS |
| 5 + 6 | 22, 23 | Hodgkin lymphoma | 25 | Yes (Am; FSH 42) | 19/85 | IVF/IVF | 37/36 | M/M | 2600/2600 | Mild preeclampsia + hypothyroidism + cervical insufficiency | CS/CS |
| 7 + 8 + 9 | 22, 24, 25 | Ewing’s sarcoma | 27 | Yes (Am; FSH 80) | 5/24/59 | IVF/NC/NC | 38/41/40 | F/F/M | 3204/3828/4015 | None/none/none | CS/VD/VD |
| 10 | 26 | Sickle cell anemia | 20 | Yes (FSH 98; LH 32) | 6 | NC | 38 | F | 3700 | NS | CS |
| 11 | 27 | Hodgkin lymphoma | 20 | Yes (Am; FSH 63; LH 34) | 8 | NC | 38 | M | 3089 | NS | NS |
| 12 + 13 (twins) | 28 | Breast cancer | 36 | Yes (Am; FSH 36; AMH 1) | 11 | IVF | 33 | M + M | 1650 + 1830 | None | CS |
| 14 | 29 | Neuroectodermic tumor | 17 | Yes (FSH 75) | 9 | NC | 38 | M | 2830 | None | NS |
| 15 | 27, 30 | Thalassemia | 19 | Yes (Am; FSH >30) | 10 | IVF | Term | M | 3026 | Cholecystolithiasis | NS |
| 16 | 31 | PID | 18 | Yes (Am) | 13 | IVF | 38 | M | 2370 | NS | CS |
| 17 | 32 | Hodgkin lymphoma | 27 | Yes (Am; FSH + LH high; AMH <0.1) | 8 | NC | 38 | M | 3360 | None | CS |
| 18 | 33 | POI | 29 | Yes (Am; FSH >40) | NS | IVF | 37 | M | 3254 | NS | NS |
| 19 | 34 | Thalassemia | 21 | Yes (FSH 72; LH 32) | 16 | NC | 39 | F | 3970 | None | CS |
| 20 + 21 (twins) | 35, 36 | Granulosa cell tumor | 25 | Yes (FSH > 120) | 7 | IVF | 37 | F + F | 3320 + 3262 | Threatened preterm labor | CS |
| 22 | 37 | Bilateral dermoid cysts | 20 | Yes (Am; FSH >30) | 5 | IVF | 38 | M | 3500 | NS | CS |
| 23 | 31 | Microscopic polyangitis | 27 | Yes (FSH 235; LH 98) | 14 | IVF | 37 | F | 2030 | HELLP syndrome | VD |
| 24 | 23 | PNH | 18 | Yes (Am; FSH) | 57 | NC | 40 | M | 3351 | None | VD |
| 25 | 38 | POI | 37 | Yes (Am; FSH >35) | NS | IVF | 38 | F | 2970 | NS | CS |
| 26 | 39 | Sickle cell anemia | 13 | Yes (FSH 59; LH 32) | >24 | NC | NS | M | 3140 | None | VD |
| 27 | 40 | Non-Hodgkin lymphoma | 24 | Yes (Am; FSH 24; AMH <1) | 31 | NC | 39 | F | 2920* | None | VD |
| 28 | 40 | Hodgkin lymphoma | 22 | Yes (FSH 35; AMH < 1) | 25 | IVF | 40 | M | 3335* | None | VD |
| 29 | 41 | Ewing’s sarcoma | 23 | Yes (Am; FSH 113; LH 72) | 12 | IVF | 38 | F | 2970 | None | CS |
| 30 | 42 | Neuroectodermic tumor | 28 | Yes | 4 | IUI | 37 | M | 2900 | None | CS |
| 31 | 13 | Non-Hodgkin lymphoma | 23 | Yes (FSH 47; LH 33; AMH <0.2) | >8 | IVF | 39 | F | 3617 | None | VD |
aFSH and LH in IU/L; AMH in pmol/L
Diagnosis
PID pelvic inflammatory disease, POI premature ovarian insufficiency, PNH paroxystic nocturnal hemoglobinuria
Sign of menopause before transplantation
Am amenorrheic, <dL under detectable limit
Pregnancy
NC naturally conceived, IVF in vitro fertilization
Birth weight
* Information from personal communication
Pregnancy complications
/ illustrates different births, HELLP syndrome a life-threatening pregnancy complication, usually considered to be a variant of preeclampsia. Late in pregnancy or right after delivery, the woman develops hemolysis (H), elevated liver enzymes (EL), and a low platelet count (LP)
Delivery mode
NS not specified, CS caesarean section, VD vaginal delivery