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. 2017 Mar 22;8:320. doi: 10.3389/fimmu.2017.00320

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Copyright © 2017 Dai, Huang, Huang, Chen, Yang and Jiang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Antigen-presenting cells and TGF-β are necessary for upregulation of Rik expression. (A) Rik expression in CD8⁺ T cells after treatment. Left panel: representative Immunoblot image. Right panel: statistics. Fresh: freshly isolated CD8⁺ T cells. N: no activation. A: activation with BALB/c splenocytes depleted of T cells. V: phosphate-buffered saline (PBS). N = 3 per group. (B) Rik expression in CD8⁺ T cells after treatment with agonistic antibodies or BALB/c splenocytes. Left panel: representative Immunoblot image. Right panel: statistics. Abs: agonistic antibodies. Cells: BALB/c splenocytes. V: PBS. N = 3 per group (*p < 0.05; ***p < 0.001).