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. 2017 Mar 22;8:99. doi: 10.3389/fneur.2017.00099

Figure 1.

Figure 1

Experimental paradigm for the evaluation of light-entrained and free-running circadian rhythms in interleukin (IL)-6 knockout (IL-6 KO) and wild-type (WT) mice. Illustration of the temporal course (in days) for the analysis of circadian behavioral locomotor activity in IL-6 KO and WT mice under light-entrainment [light/dark (LD): 12 h light and 12 h dark phase; white boxes] and during settings of free-running rhythms [dark/dark (DD): 24 h constant darkness, black boxes].