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. 2017 Mar 22;8:99. doi: 10.3389/fneur.2017.00099

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Copyright © 2017 Monje, Cicvaric, Acevedo Aguilar, Elbau, Horvath, Diao, Glat and Pollak.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Entrainment period (T), wheel-running activity, and bout analysis in under light-entrained [light/dark] conditions in interleukin (IL)-6 knockout (IL-6 KO) and wild-type (WT) mice. Analysis of the light-entrained circadian behavioral locomotor activity in IL-6 KO and WT mice (n = 9–11 per group) demonstrating comparable (A) T and wheel-running activity during the (B) alpha and (C) rho phase and in (D) total amounts. (E) Significantly increased quantity of activity bouts in IL-6 KO compared with WT mice with unaltered (F) bout length and (G) activity counts/bout. All data are displayed as mean ± SEM; *p < 0.05.