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. 2017 Mar 22;11:84. doi: 10.3389/fncel.2017.00084

Figure 1.

Figure 1

KCNQ1OT1 expression in glioma tissues and human glioma cells. Knockdown of KCNQ1OT1 restrained cell proliferation, promoted apoptosis and restrained migration and invasion in human glioma cells. (A) KCNQ1OT1 expression in normal brain tissues (NBTs), different grades of human glioma tissues. Data are presented as the mean ± standard deviation (SD; n = 15, each group). *P < 0.01 vs. NBTs group. (B) Expression levels of KCNQ1OT1 in human normal astrocytes and human glioma cell lines U87 and U251. Data are presented as the mean ± SD (n = 5, each group). *P < 0.01 vs. Normal human astrocytes (NHA) group. (C) Knockdown efficiency of KCNQ1OT1 inhibition. (D) CCK-8 assay was used to determine the proliferation effect of KCNQ1OT1 on human glioma cells. (E) Flow cytometry analysis of KCNQ1OT1 knockdown on glioma cells. (F) Quantification of migration and invasion of KCNQ1OT1 knockdown of human glioma cells. Representative images and accompanying statistical plots were presented. Data are presented as the mean ± SD (n = 5, each group). *P < 0.05 vs. sh-NC group. Scale bars represent 20 μm. **P < 0.01 vs. NBTs group.