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. 2017 Mar 22;11:84. doi: 10.3389/fncel.2017.00084

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Copyright © 2017 Gong, Zheng, Liu, Liu, Guo, Gao, Tao, Chen, Li, Ma and Xue.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sh-KCNQ1OT1 phenotype was reversed by over expression of CCNE2. (A) CCK-8 assay was used to determine the proliferation effect of sh-KCNQ1OT1 + CCNE2 on human glioma cells. *P < 0.05 vs. Control group; ^#P < 0.05 vs. sh-KCNQ1OT1 group. (B) Flow cytometry analysis of human glioma cells with the expression of CCNE2 changed. *P < 0.05 vs. Control group; ^#P < 0.05 vs. sh-KCNQ1OT1 group. (C) Quantification of migration and invasion cells with the expression of CCNE2 changed. Representative images and accompanying statistical plots were presented. *P < 0.05 vs. Control group; ^#P < 0.05 vs. sh-KCNQ1OT1 group. Scale bars represent 20 μm.