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. 2017 Mar 22;11:84. doi: 10.3389/fncel.2017.00084

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Copyright © 2017 Gong, Zheng, Liu, Liu, Guo, Gao, Tao, Chen, Li, Ma and Xue.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MiR-370 inhibited human glioma cells malignant progression via targeting to CCNE2 3′-UTR. CCNE2 activated the YAP1 signal pathways. (A) CCK-8 assay was used to evaluate the proliferation effect of miR-370 and CCNE2 changed on human glioma cells at 24 h, 48 h and 72 h. (B) Flow cytometry analysis of human glioma cells with the expression of miR-370 and CCNE2 changed. (C) Quantification of migration and invasion cells with the expression of miR-370 and CCNE2 changed. Representative images and accompanying statistical plots were presented. Data are presented as the mean ± SD (n = 5, each group). *^#P < 0.05 vs. miR-370 + CCNE2 group. Scale bars represent 20 μm. (D) Western blot analysis of the YES-associated protein (YAP) pathways regulated by CCNE2 in human glioma cells. Data are presented as the mean ± SD (n = 5, each group). *^▲^#P < 0.05 vs. Sh-KCNQ1OT1 group and pre-miR-370 group.