Table 2.

The binding of [³H]CP55.940 to CB₁ receptors in various brain areas in OBX rats

	SHAM	OBX
Motor cortex (I–III layers)	100.0 ± 7.97	119.9 ± 8.08
Motor cortex (IV–VI layers)	100.0 ± 7.64	101.3 ± 5.68
Prelimbic cortex (I–III layers)	100.0 ± 10.56	92.1 ± 5.11
Prelimbic cortex (IV–VI layers)	100.0 ± 5.08	143.9 ± 9.63**
Infralimbic cortex	100.0 ± 10.10	95.8 ± 5.22
Frontal cortex (II–III layers)	100.0 ± 8.45	109.6 ± 4.49
Frontal cortex (V layer)	100.0 ± 12.07	101.3 ± 5.87
Cingulate cortex	100.0 ± 6.28	111.8 ± 5.20
Laterodorsal striatum	100.0 ± 5.93	82.1 ± 3.53*
Mediodorsal striatum	100.0 ± 4.80	103.1 ± 6.29
Nucleus accumbens core	100.0 ± 10.65	100.1 ± 9.58
Nucleus accumbens shell	100.0 ± 13.75	89.9 ± 9.20
Amygdala	100.0 ± 7.98	102.7 ± 5.38
Dentate gyrus (hippocampus)—bregma—3.30	100.0 ± 4.15	112.6 ± 6.53
CA1 layer (hippocampus)—bregma—3.30	100.0 ± 6.15	93.9 ± 7.20
CA2 layer (hippocampus)—bregma—3.30	100.0 ± 12.66	121.3 ± 13.64
CA3 layer (hippocampus)—bregma—3.30	100.0 ± 4.75	101.5 ± 11.83
Dentate gyrus (hippocampus)–bregma—5.30	100.0 ± 6.67	95.0 ± 1.71
CA1 layer (hippocampus)—bregma—5.30	100.0 ± 10.85	114.1 ± 4.68
CA2 layer (hippocampus)—bregma—5.30	100.0 ± 8.78	112.0 ± 10.76
CA3 layer (hippocampus)—bregma—5.30	100.0 ± 7.15	94.3 ± 7.37
Ventral tegmental area	100.0 ± 4.85	97.1 ± 8.15
Substantia nigra	100.0 ± 4.86	99.9 ± 5.95

The number of animals in all examined groups was n = 6. Data are presented as the mean percent binding (±S.E.M.) relative to control (SHAM)

OBX bulbectomized rats, SHAM SHAM-operated rats

*p < 0.05; **p < 0.01 vs. SHAM