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. Author manuscript; available in PMC: 2017 Mar 22.
Published in final edited form as: Sci Transl Med. 2015 Apr 1;7(281):281ra45. doi: 10.1126/scitranslmed.aaa5171

Figure 5. Cryoinjury and rNRG1 administration induce gene regulation patterns that parallel structural and functional changes.

Figure 5

Mice underwent cryoinjury on day 1 of life (P1) and were treated with BSA or rNRG1 according to the early administration protocol. Expression profiling was performed at 10 dpi with 5 mice per group and normalized to sham (n = 5). (A) Heat map shows 622 genes that were significantly regulated between BSA and rNRG1 treated mice (P<0.05). Selected genes discussed in the text are indicated. The color chart indicates fold change of expression using a log2 scale. (B) Functional annotation clustering of differentially expressed genes shows significant regulation of multiple pathways by rNRG1. GO, gene ontology.