Table 1. Structural subsets of human γδT cells.
| Structural subset | Paired Vγ gene usage | Distribution | Activation stimulus and/or γδTCR ligands | References |
|---|---|---|---|---|
| Vδ1 | Vγ2/3/4/5/8/9 | PB, skin, gut, spleen, liver | MICA/B; ULBPs; B7-H6; CD1c; CD1d; SEB | 35, 39, 44, 45, 46 |
| Vδ2 | Vγ9 | PB | Phosphoantigens; F1-ATPase; BTN3A1; hMSH2; MICA/B; ULBPs; SEs; TSST-1; Nectin-like-5; | 20, 24, 27, 28, 31, 32, 33 |
| Vδ3 | Vγ2/3 | PB, liver | CD1d | 50, 52 |
| Vδ5 | Vγ4 | PB | EPCR | 53 |
Abbreviations: BTN3A1, butyrophilin3A1; EPCR, endothelial protein C receptor; hMSH2, human MutS homolog 2; MHC, major histocompatibility complex; MICA/B, MHC class I chain-related antigens A and B; PB, peripheral blood; ULBP, UL16-binding protein; SE, staphylococcal superantigens; TSST-1, toxic shock syndrome toxin-1.