. 2016 Nov 28;14(3):245–253. doi: 10.1038/cmi.2016.55

Table 2. Functional subsets of human γδT cells.

Functional subsets	Polarization	References
IFN-γ-producing γδT	IPP+IL-12+IL-4 antibody; IL-2+IL-21; nonpeptide antigens+IL-21; IL-2+IL-15	^{57, 58, 59, 60, 61}
IL-4-producing γδT	IPP+IL-4+IL-12 antibody	⁵⁷
γδT-APC	Microbial product	⁶
γδT_FH	IL-21; HMB-PP+IL-21	^{56, 68}
γδTreg	TGF-β+IL-15; Vδ1 TCR antibody+ TGF-β1; IP-10	^{70, 71, 72, 73}
γδT17	IL-7+TCR agonists; IL-23; phosphoantigens+IL-1β+TGF-β+IL-6+IL-23; IL-6+IL-1β+TGF-β	^{14, 75, 76, 77}

Abbreviations: APC, antigen-presenting cell; γδTreg, regulatory γδT; HMB-PP, (E)-4-Hydroxy-3-methyl-but-2-enyl pyrophosphate; IFN, interferon; IL, interleukin; IPP, Isopentenyl pyrophosphate; TCR, T-cell receptor; TGF, tumor growth factor.