Table 1.
Genotype and allele frequency of the RAGE gene in the patients with schizophrenia and controls.
| dbSNP ID | Schizophrenia | Control | p value | OR (95% CI) |
|---|---|---|---|---|
| n = 923 (%) | n = 874 (%) | |||
| G82S | ||||
| Genotype | ||||
| GG | 535 (58.0) | 533 (61.0) | 0.426a | |
| GS | 336 (36.4) | 296 (33.9) | ||
| SS | 52 (5.6) | 45 (5.1) | ||
| GS + SS | 388 (42.0) | 341 (39.0) | 0.192b | 1.134 (0.939–1.369) |
| Allele | ||||
| G | 1406 (76.2) | 1362 (77.9) | 1.000 (reference) | |
| S | 440 (23.8) | 386 (22.1) | 0.212 | 1.104 (0.945–1.290) |
|
| ||||
| -374T/A | ||||
| Genotype | ||||
| TT | 704 (76.3) | 688 (78.7) | 0.341a | |
| TA | 199 (21.6) | 173 (19.8) | ||
| AA | 20 (2.2) | 13 (1.5) | ||
| TA + AA | 219 (23.7) | 186 (21.3) | 0.215c | 1.151 (0.922–1.437) |
| Allele | ||||
| T | 1607 (87.1) | 1549 (88.6) | 1.000 (reference) | |
| A | 239 (12.9) | 199 (11.4) | 0.152 | 1.158 (0.947–1.415) |
|
| ||||
| -429T/C | ||||
| Genotype | ||||
| TT | 807 (87.4) | 733 (83.9) | 0.081a∗ | |
| TC | 113 (12.2) | 137 (15.7) | ||
| CC | 3 (0.3) | 4 (0.5) | ||
| TC + CC | 116 (12.6) | 141 (16.1) | 0.031d | 0.747 (0.573–0.974) |
| Allele | ||||
| T | 1727 (93.6) | 1603 (91.7) | 1.000 (reference) | |
| C | 119 (6.4) | 145 (8.3) | 0.034 | 0.762 (0.592–0.980) |
OR: odds ratio; 95% CI: 95% confidence interval. aGlobal test for the three different genotypes. bCalculations were performed, GS + SS versus GG. cCalculations were performed, TA + AA versus TT. dCalculations were performed, TC + CC versus TT. ∗Fisher's exact test.