Table 3.
Spearman's rho correlation coefficient and significance values for age, TSH, fT4, and thyroid nodule size with CBMN-cyt assay parameters and plasma 8-OHdG levels in patients with multinodular goiter and control subjects.
| MN frequency (%) |
NPB frequency (%) |
NBUD frequency (%) |
Frequency of apoptotic cells (%) |
Frequency of necrotic cells (%) |
NDI | Plasma 8-OHdG levels |
|
|---|---|---|---|---|---|---|---|
| Patients with multinodular goiter |
|||||||
| Age (years) | |||||||
| r | −0.017 | −0.133 | 0.065 | 0.205 | 0.214 | −0.411∗ | 0.240 |
| p | 0.929 | 0.475 | 0.730 | 0.269 | 0.247 | 0.022 | 0.194 |
| TSH (mIU/L) | |||||||
| r | −0.089 | 0.029 | −0.248 | 0.381∗ | 0.194 | −0.049 | 0.318 |
| p | 0.646 | 0.880 | 0.195 | 0.042 | 0.312 | 0.802 | 0.093 |
| fT4 (ng/dL) | |||||||
| r | 0.166 | 0.005 | 0.061 | −0.197 | −0.099 | 0.362 | −0.512∗∗ |
| p | 0.388 | 0.980 | 0.755 | 0.306 | 0.611 | 0.053 | 0.005 |
| Thyroid nodule size (mm) | |||||||
| r | −0.243 | 0.105 | 0.110 | −0.178 | −0.114 | −0.114 | −0.279 |
| p | 0.276 | 0.642 | 0.628 | 0.428 | 0.615 | 0.615 | 0.209 |
|
| |||||||
| Control subjects | |||||||
| Age (years) | |||||||
| r | 0.176 | 0.640∗∗ | 0.578∗ | 0.053 | −0.190 | −0.339 | 0.319 |
| p | 0.485 | 0.004 | 0.012 | 0.833 | 0.449 | 0.169 | 0.197 |
| TSH (mIU/L) | |||||||
| r | 0.142 | −0.150 | −0.354 | 0.075 | 0.424 | −0.039 | 0.317 |
| p | 0.574 | 0.552 | 0.149 | 0.769 | 0.080 | 0.877 | 0.200 |
| fT4 (ng/dL) | |||||||
| r | 0.342 | −0.282 | −0.322 | −0.016 | 0.247 | −0.153 | −0.473∗ |
| p | 0.165 | 0.257 | 0.193 | 0.950 | 0.322 | 0.545 | 0.047 |
∗Correlation is significant at the 0.05 level, and ∗∗correlation is significant at the 0.01 level.
BN cells, binucleated cells; MN, micronucleus; NBUDs, nuclear buds; NPBs, nucleoplasmic bridges; NDI, nuclear division index; and 8-OHdG, 8-hydroxy-2′-deoxyguanosine.