Table 2.
Epidemiology results of C. bovis-contaminated cryopreserved PDX tissue as the source of infection
| Case | Lab | Time (d) between Cryo-PDX and C. bovis detectiona | No. of C. bovis DNA copies (qPCR assay) in replicate Cryo-PDX | C. bovis incidence in surveyed Cryo-PDXb | No. of Cryo-PDX lines causing infection after implantationc |
| 1 | A | 27 | 370 | 60% | 1 of 6 (16%) |
| 2 | B | 11 | 568 | 100% | Unknown |
| 3 | B | 25 | 382 | 100% | 1 of 4 (25%) |
a
Detected by EAD testing after PDX implantation
b
Results previously reported in reference 16
c
Total represents only cryopreserved PDX tissues that were harvested prior to C. bovis elimination efforts