Table 2. Statistically significant metabolite levels of all histologies between IDH status and tumor grade.
| All histologies | (med ± SE) | All histologies | (med ± SE) | ||
|---|---|---|---|---|---|
| Metabolite | IDH-mut | IDH-wt | Grade II | Grade III | GBM |
| Cho Cho | 7.4 ± 1.26 | 3.72 ± 0.73 | — | — | — |
| GPC | 20.2 ± 3.64 | 9.2 ± 2.09 | — | — | — |
| PC | 11.54 ± 3.0 | 6.58 ± 1.37 | 9.38 ± 1.68 | 14.26 ± 5.04 | 26.44 ± 15.08 |
| tCho | 38.18 ± 5.81 | 21.03 ± 3.16 | 23.05 ± 5.01 | 36.31 ± 9.37 | 64.27 ± 18.48 |
| GSH | — | — | 11.52 ± 1.54 | 12.76 ± 4.51 | 17.28 ± 7.06 |
| hTau | — | — | 2.05 ± 0.63 | — | 4.07 ± 0.77 |
| Tau | — | — | 14.87 ± 2.3 | 31 ± 4.24 | 29.6 ± 10.1 |
| 2HG | 8.17 ± 1.01 | 2.82 ± 0.47 | 5.43 ± 1.1 | 7.88 ± 1.57 | 13.7 ± 2.57 |
| Glu | 49.84 ± 4.99 | 94.18 ± 33.03 | 41.76 ± 6.17 | 52.18 ± 8.13 | 79.79 ± 24.65 |
| Gln | — | — | 33.09 ± 5.64 | — | 38.24 ± 15.39 |
| Glc | — | — | 31.31 ± 5.12 | — | 35.74 ± 44.41 |
| Ala | — | — | 11.73 ± 2.31 | 17.12 ± 9.49 | 20.87 ± 10.88 |
| Asp | — | — | 37.83 ± 4.89 | 39.33 ± 5.83 | 71.32 ± 27.7 |
| GABA | 2.92 ± 0.42 | 6.48 ± 3.04 | — | — | — |
| Gly | — | — | 33.46 ± 5.67 | 46.12 ± 8.57 | 78.03 ± 29.75 |
| Bet | — | — | 0.85 ± 0.1 | 0.88 ± 0.18 | 1.27 ± 0.6 |
Mixed-effects logistical regression results demonstrated significant differences in various metabolite levels between IDH genotype and tumor grades (p < 0.05). Metabolite levels are presented for statistically significant metabolites at a tissue sample level. These results are presented as median spectral areas for each metabolite as fit by HR-QUEST.