Table 3.
Effect of different drug treatment on body weight and blood glucose at different intervals.
| Group | Treatment | Body weight (gm) | FBG (mg/dl) | ||||
|---|---|---|---|---|---|---|---|
| 0th week | 1st week | 8th week | 0th week | 1st week | 8th week | ||
| I | Normal animals (Sham control) | 225.8 ± 8.1 | 226.2 ± 8.2 | 229.4 ± 7.9 | 98.1 ± 8.8 | 97.8 ± 8.6 | 98.3 ± 7.2 |
| II | Diabetic control | 224.9 ± 7.2 | 224.5 ± 7.4 | 194.7 ± 9.2∧ | 96.4 ± 7.5 | 294.8 ± 17.8 | 346.2 ± 27.4∧ |
| III | Diabetic animals + Insulin (5 IU/kg) | 222.5 ± 8.4 | 221.8 ± 8.6 | 217.5 ± 7.9 | 101.2 ± 6.9 | 284.5 ± 21.6 | 132.7 ± 14.8* |
| IV | Diabetic animals+ Pregabalin (100 mg/kg)+ Insulin (5 IU/kg) | 226.2 ± 9.4 | 225.7 ± 9.6 | 219.2 ± 7.5 | 98.7 ± 6.8 | 289.4 ± 24.8 | 137.2 ± 16.4* |
| V | Diabetic animals+ ARBME (200 mg/kg)+ Insulin (5 IU/kg) | 223.8 ± 6.6 | 223.2 ± 6.8 | 216.8 ± 8.4 | 100.6 ± 7.4 | 275.9 ± 18.4 | 126.5 ± 14.3* |
| VI | Diabetic animals+ ARBME (400 mg/kg)+ Insulin (5 IU/kg) | 226.3 ± 7.9 | 225.7 ± 8.1 | 214.8 ± 9.3 | 97.5 ± 6.7 | 296.7 ± 22.4 | 115.8 ± 13.6* |
| VII | Diabetic animals+ ARBWF (50 mg/kg) Insulin+ (5 IU/kg) | 223.4 ± 7.8 | 222.8 ± 7.6 | 214.3 ± 6.2 | 101.8 ± 8.2 | 272.6 ± 26.1 | 122.9 ± 14.3* |
| VIII | Diabetic animals+ ARBWF (100 mg/kg)+ Insulin (5 IU/kg) | 226.9 ± 9.9 | 226.5 ± 10.3 | 217.6 ± 7.7 | 98.6 ± 7.3 | 294.3 ± 18.3 | 107.5 ± 10.9*$ |
| IX | Diabetic animals+ ZJME (200 mg/kg)+ Insulin (5 IU/kg) | 226.3 ± 8.5 | 225.9 ± 8.3 | 215.2 ± 8.6 | 99.4 ± 8.4 | 277.4 ± 20.6 | 131.2 ± 14.6* |
| X | Diabetic animals+ ZJME (400 mg/kg)+ Insulin (5 IU/kg) | 224.1 ± 9.3 | 223.6 ± 9.5 | 214.7 ± 6.8 | 101.2 ± 8.1 | 295.2 ± 16.8 | 109.6 ± 13.7*$# |
| XI | Diabetic animals+ ZJWF (50 mg/kg)+ Insulin (5 IU/kg) | 224.9 ± 10.2 | 224.3 ± 10.6 | 217.8 ± 7.9 | 97.7 ± 7.5 | 276.1 ± 27.5 | 124.8 ± 16.3* |
| XII | Diabetic animals+ ZJWF (100 mg/kg)+ Insulin (5 IU/kg) | 226.6 ± 9.6 | 226.3 ± 9.8 | 216.4 ± 10.2 | 96.5 ± 7.2 | 284.9 ± 21.4 | 103.6 ± 12.8*$# |
All the results were presented in mean ± S.D (n = 6).
∧
p ≤ 0.05 in comparison of diabetic animals (Group-II) with normal animals (Group-I).
*
p ≤ 0.05 in comparison of drug treated groups (Group: III–XII) with diabetic control group (Group: II).
$
p ≤ 0.05 in comparison of drug treatment along with insulin treated groups (Group: IV–XII) with insulin alone treated group (Group-III).
#
p ≤ 0.05 in comparison between the different doses of same treatment groups. ARBME, A. reticulata bark methanol extract; ARBWF, A. reticulata bark water fraction; ZJME, Z. jujuba root bark methanol extract; ZJWF, Z. jujuba root bark water fraction.