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. 2017 Mar 22;7:45228. doi: 10.1038/srep45228

Figure 5. A different HCV variant was selected in chimeric mice with human liver xenografts.

Figure 5

(A) Viral RNA levels in the sera of chimeric mice with human liver were determined by qRT-PCR at 1, 3, 5 and 12 days post-infection with HCVcc/Huh7. (B) Viral sequences including E753D and Q2119H were amplified by PCR and frequencies of mutations were evaluated by deep sequencing. (C) Distribution of mutations in chimeric mice-adapted and Huh7-re-adapted HCV. (D) Infectious titers in the supernatants on serial passages of Huh7.5.1 cells infected with HCV derived from chimeric mice at 12 days post-infection.