Table 2. Quantitative association analysis of candidate genes and changes in phenotype at 12 weeks.
| SNP | Gene | Risk allele | P | P (adjusteda) |
|---|---|---|---|---|
| All patients | ||||
| ΔBMI | ||||
| rs182052 | ADIPOQ | A | 0.019 | 0.019 |
| rs11777927 | TOX | A | 0.009 | 0.009 |
| rs351320 | EPHA7 | G | 0.025 | 0.035 |
| rs3731245 | CDKN2A/B | A | 0.040 | 0.040 |
| rs2811708 | CDKN2A/B | T | 0.039 | 0.044 |
| ΔWHR | ||||
| rs822396 | ADIPOQ | G | 0.003 | 0.005 |
| rs1501299 | ADIPOQ | A | 0.040 | 0.045 |
| rs6265 | BDNF | G | 0.002 | 0.002 |
| rs11030104 | BDAF | G | 0.001 | 0.002 |
| FEP groupb | ||||
| ΔBMI | ||||
| rs279858 | GABRA2 | G | 0.029 | — |
| rs249496 | PCAF | A | 0.019 | — |
| rs2811708 | CDKN2A/B | T | 0.028 | — |
| rs6567160 | MC4R | C | 0.041 | — |
| ΔWHR | ||||
| rs35747495 | PCAF | T | 0.024 | — |
| rs10811661 | CDKN2A/B | C | 0.031 | — |
| rs489693 | MC4R | A | 0.011 | — |
| OLZ groupb | ||||
| ΔBMI | ||||
| rs279858 | GABRA2 | G | 0.021 | — |
| rs10968576 | LINGO2 | G | 0.020 | — |
| ΔWHR | ||||
| rs822396 | ADIPOQ | G | 0.047 | — |
| rs6265 | BDNF | G | 0.020 | — |
| rs11030104 | BDAF | G | 0.020 | — |
| RIS groupb | ||||
| ΔBMI | ||||
| rs3776871 | PAM | A | 0.039 | — |
| rs7799039 | LEP | G | 0.002 | — |
| rs3731245 | CDKN2A/B | A | 0.006 | — |
| rs2811708 | CDKN2A/B | T | 0.002 | — |
| rs6567160 | MC4R | C | 0.006 | — |
| rs489693 | MC4R | A | 0.018 | — |
ΔBMI, change in body mass index; ΔWHR, change in waist-to-hip ratio.
aAll the dependent variables were adjusted for age and gender.
bNo age and gender adjusted phenotypes were used in subgroups due to limited sample size.