Figure 8. A schematic illustration of the molecular mechanism of TNF-α-induced ICAM1 expression and leukocyte adhesion/transmigration in HBMVECs.

TNF-α reduces the interaction between G9a and the Icam1 promoter region, while enhancing the interaction with KDM4B. This contributes to decreased H3K9 methylation of the Icam1 promoter region and consequent ICAM1 expression, which lead to leukocyte adhesion/transmigration across endothelial cells.