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. 2017 Mar 22;7:44989. doi: 10.1038/srep44989

Figure 1. Dopaminergic neuron-specific Ndufs4 knockout does not cause dopamine neuron death.

Figure 1

(a) Representative photomicrographs of TH immunostaining of SNpc. cKO: conditional knockout of Ndufs4 (Dat-cre/Ndufs4lox/lox) mice; control: Ndufs4lox/lox littermates. Bar, 200 μm. (b) Quantification of the total number of TH+ neurons in the SNpc. (c) Quantification of the total number of apoptotic, TUNEL+ cells in the SNpc. n.s. not statistically significant. (e,f) Representative TH staining of striatal (e) and amygdalar (f) tissue from Dat-cre/Ndufs4lox/lox (cKO) mice and Ndufs4lox/lox (Control) mice. Bar, 200 μm. (g,h) Quantification of TH staining intensity in the striatum (g) and amygdala (h). AU, arbitrary units. n.s. not statistically significant.