Table 1. Missense mutations found in the 3₁₀-helix formed by D580-S584 in hemophilia A patients.

Mutation	Mutation Effect	Reported Severity
c.1795G > C	p.D580H	Severe
c.1796A > T	p.D580V	Severe
c.1798G > A	p.E581K	Severe
c.1798G > C	p.E581Q	Severe
c.1800G > T	p.E581D	Severe
c.1801A > C	p.N582H	Moderate
c.1801A > G	p.N582D	Severe
c.1803C > G	p.N582K	Severe
c.1804C > G	p.R583G	Mild
c.1807A > G	p.S584G	Mild
c.1807A > T	p.S584C	Severe
c.1808G > C	p.S584T	Severe
c.1808G > T	p.S584I	Not reported
c.1809C > G	p.S584R	Moderate/Severe
c.1810T > C	p.W585R	Severe
c.1811G > T	p.W585L	Moderate
c.1812G > C	p.W585C	Severe
c.1812G > T	p.W585C	Severe