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. Author manuscript; available in PMC: 2017 Jun 5.
Published in final edited form as: Nature. 2016 Dec 5;541(7635):102–106. doi: 10.1038/nature20789

Figure 4. SFA-1 promotes longevity.

Figure 4

AL and DR-fed splicing reporter at day 8 in a, aak-2(ok524), b, daf-16(mu86), and c, (raga-1(ok386) mutant backgrounds. Images are representative of at least 2 independent experiments. d, Effect of sfa-1 RNAi on raga-1(ok386) mutant lifespan (p=0.6733 vs. WT+sfa-1 RNAi). e, Lifespan analysis of sfa-1 RNAi in long-lived rsks-1(ok1255) (p=0.0944 vs. WT+sfa-1 RNAi). f, Overexpression of SFA-1 affects WT lifespan (p<0.0001). g, Model for role of SFA-1 in DR and mTORC1 pathway longevity. p values: log-rank test, n=100 worms/condition.