Extended Data Table 1.

Effects of splicing factor RNAi on lifespan in WT and DR (eat-2(ad1116)) C. elegans

Treatment	Median lifespan N2 (days)	Median lifespan eat-2(ad1116) (days)	p-value N2 RNAi vs. eat-2(ad1116) RNAi	% Lifespan extension eat-2(ad1116)	FUDR
ev *	22	34	< 0.0001	55	+
hrpf-1	22	34	< 0.0001	55	+
repo-1	20	22	< 0.0001	10	+
snr-1	13	13	0.5147	0	+
sym-2	22	34	< 0.0001	55	+
ev	17	31	< 0.0001	82	+
sfa-1	20	20	0.9783	0	+
ev †	19	25	< 0.0001	32	+
hrp-2	11	11	0.1617	0	+
ev ‡	17	25	< 0.0001	47
uaf-2	12	12	0.0299	0
hrp-1	18	23	< 0.0001	28
phi-9	18	25	< 0.0001	39
ev §	17	22	< 0.0001	29
snr-2	11	13	0.3546	18
er ¶	20	25	< 0.0001	25
rsp-3	17	25	< 0.0001	47
rsp-2	20	27	< 0.0001	35
smu-1	17	25	< 0.0001	47
ev	21	24	< 0.0001	14
uaf-1	11	9	0.6094	-18

ev, empty vector control,

^*survival curves in Extended Data Figures 2k, l, 9b,

^†Extended Data Figure 2m,

^‡Extended Data Figure 2n,

^§Extended Data Figure 2o,

^¶Extended Data Figure 2p.