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. 2016 Sep 13;122(1):20–27. doi: 10.1080/03009734.2016.1225870

Figure 1.

Figure 1.

In vivo effects of long-term BPA exposure on VEGF, ACE, eNOS, and VEGFR2 mRNA expressions in rat cardiac tissue. A: Rats exposed to 0.025 μg/mL, 0.25 μg/mL, and 2.5 μg/mL BPA showed increased mRNA expression of VEGF compared to fructose controls and water controls. B: VEGFR2 mRNA expression was increased in rats exposed to 0.025 μg/mL BPA compared to fructose controls and water controls. C: ACE1 mRNA expression was increased in rats exposed to 0.025 μg/mL, 0.25 μg/mL, and 2.5 μg/mL compared to fructose controls and in rats exposed to 0.025 μg/mL BPA compared to water controls. D: Rats exposed to 0.025 μg/mL and 2.5 μg/mL BPA showed increased eNOS mRNA expression compared to fructose controls and water controls. Each bar represents mean normalized mRNA expression ± SEM of four animals, each analyzed in three replicates. #P < .05, ##P < .01, ###P < .001, compared to fructose controls. *P < .05, **P < .01, ***P < .001, compared to water controls.