Table 3.
Influence of rabPXL01 in HA on mRNA expression of matrix proteins, growth factors, and inflammatory mediators by injured tendons and tendon sheaths.
| Percent of corresponding control (untreated tendons and tendon sheaths) |
P values |
||||||
|---|---|---|---|---|---|---|---|
| Molecule | Group | Day 1 | Day 3 | Day 6 | Day 1 | Day 3 | Day 6 |
| Collagen I | Tendon PXL01 | 390.2 | 144.2 | 112.3 | .13 | .387 | .742 |
| Sheath PXL01 | 60.1 | 87.2 | 42.2 | .494 | .563 | .082 | |
| Collagen III | Tendon PXL01 | 973.9 | 157.8 | 96.4 | .003 | .387 | .889 |
| Sheath PXL01 | 70.8 | 69.9 | 58.4 | .556 | .563 | .065 | |
| Cox-2 | Tendon PXL01 | 263.5 | 121.1 | 93.8 | .214 | .506 | .896 |
| Sheath PXL01 | 71.7 | 76 | 56.7 | .331 | .416 | .094 | |
| iNOS | Tendon PXL01 | 398 | 175.7 | 232.6 | .085 | .043 | .298 |
| Sheath PXL01 | 114.7 | 98.9 | 55.1 | .687 | .969 | .106 | |
| IL-1β | Tendon PXL01 | 153.6 | 110.3 | 82.7 | .194 | .782 | .581 |
| Sheath PXL01 | 64.6 | 95.7 | 51.7 | .432 | .876 | .04 | |
| IL-6 | Tendon PXL01 | 177.6 | 154.4 | 163.7 | .337 | .233 | .582 |
| Sheath PXL01 | 82.2 | 81.5 | 49 | .789 | .607 | .005 | |
| IL-8 | Tendon PXL01 | 192.9 | 110.7 | 88.4 | .093 | .79 | .744 |
| Sheath PXL01 | 39.8 | 106 | 53.6 | .265 | .824 | .009 | |
| TNF-α | Tendon PXL01 | 89.9 | 131.9 | 126.4 | .742 | .473 | .441 |
| Sheath PXL01 | 66.9 | 84.9 | 56.8 | .427 | .553 | .129 | |
| TGF-β | Tendon PXL01 | 189.8 | 112 | 92 | .256 | .724 | .554 |
| Sheath PXL01 | 45.4 | 74 | 48.6 | .409 | .304 | .106 | |
| αSMA | Tendon PXL01 | 333 | 133.2 | 154.4 | .367 | .602 | .447 |
| Sheath PXL01 | 43.1 | 63.2 | 56.9 | .304 | .161 | .139 | |
Levels of mRNA in tendons and tendon sheaths for each molecule are shown as percent of corresponding control (the tendon and tendon sheath of the untreated paw). P values are shown for each molecule on days 1, 3, and 6 after surgery.