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. 2016 Oct 3;122(1):35–42. doi: 10.1080/03009734.2016.1228721

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© 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Dose response curves of migrating neutrophils to gradients of IL-8. Leukocytes from newborn infants (A) (n = 3) and adults (B) (n = 3) were exposed to different concentrations of IL-8 (0.1 μM and 1 μM) and buffer. Results are presented as mean ± SEM, and chemotaxis (taxis) was distinguished from random migration (random). C: Example of different patterns of neutrophil migration with 4× magnification, towards buffer (negative control), and gradients of IL-8 in one neonate and one adult. *P < .05 indicates significant difference between neonates and adults at 0.1 μM IL-8, and **P < .001 at 1 μM IL-8. §P < .05 indicates significant difference between 0.1 μM and 1 μM IL-8 in adults. At all concentrations of IL-8, a significantly higher number of neutrophils from both neonates and adults migrated towards IL-8 than to buffer (#P < .001). Note: ‘random migration’ counted from B-zone; ‘taxis + random’ counted from A-zone; ‘chemotaxis’ calculated from A-zone minus B-zone.