Figure 1.

Representative ocular phenotypes in NC-specific Foxc2^−/− mutant mice at P0. (A–D) The eyeballs of control (Foxc2^F/F) (A) and NC-Foxc2^−/− (B–D) mice at P0. Neural crest-Foxc2^−/− mice exhibit smaller eyes with irregular iris and abnormal morphology in the cornea and conjunctiva. The peripheral cornea–limbus–conjunctiva regions had abnormal tissue attachment (B, C, dotted lines) with superficial hemorrhagic blood vessels (B, arrowheads). The eyes of NC-Foxc2^−/− mutants also had a corneal plaque (arrow) with blood vessels (D, inset, arrowhead).