Table 3.
The distribution of TLR-3 _7 C/A, TLR-3 c.1377C/T, and TLR-9 1237T/C genotypes in HCV patients and controls
| Genotype | Patients (100) | Control (100) | P value | OR (95% CI) | |||
|---|---|---|---|---|---|---|---|
| Count | % | Count | % | ||||
| TLR-3_ 7C/A | AA | 2 | 2.0 | 3 | 3.0 | 1.000 | 0.748 (0.122–4.599) |
| AC | 24 | 24.0 | 14 | 14.0 | 0.076 | 1.923 (0.927–3.989) | |
| CC | 74 | 74.0 | 83 | 83.0 | Reference | ||
| AA + AC | 26 | 26.0 | 17 | 17.0 | 0.121 | 1.715 (0.863–3.410) | |
| Allele A | 28 | 14 | 20 | 10 | 0.218 | 1.468 (0.796–2.698) | |
| Allele C | 172 | 86 | 180 | 90 | Reference | ||
| TLR-3-1377 C/T | TT | 6 | 6.0 | 6 | 6.0 | 0.763 | 0.833 (0.254–2.731) |
| CT | 28 | 28.0 | 39 | 39.0 | 0.094 | 0.598 (0.327–1.094) | |
| CC | 66 | 66.0 | 55 | 55.0 | Reference | ||
| TT + CT | 34 | 34.0 | 45 | 45.0 | 0.112 | 0.630 (0.356–1.115) | |
| Allele T | 40 | 20 | 51 | 25.5 | 0.190 | 0.730 (0.456–1.169) | |
| Allele C | 160 | 80 | 149 | 74.5 | Reference | ||
| TLR-9 1237T/C | CC | 3 | 3.0 | 6 | 6.0 | 0.396 | 0.474 (0.019–2.464) |
| TC | 19 | 19.0 | 20 | 20.0 | 0.813 | 0.901 (0.381–2.130) | |
| TT | 78 | 78.0 | 74 | 74.0 | Reference | ||
| CC + TC | 22 | 22.0 | 26 | 26.0 | 0.683 | 0.803 (0.365–1.768) | |
| Allele C | 25 | 12.5 | 32 | 16 | 0.405 | 0.750 (0.380–1.479) | |
| Allele T | 175 | 87.5 | 168 | 84 | Reference | ||
CI = confidence Interval; OR = odds ratio. P value < 0.05 is considered significant.