Table 4.
Association of gene polymorphism and degree of liver fibrosis
| Genotype | Degree of liver fibrosis | P value | OR (95% CI) | ||||
|---|---|---|---|---|---|---|---|
| Mild hepatic fibrosis F1 (N = 65) | Advanced hepatic fibrosis F2, F3 (N = 35) | ||||||
| Count | % | Count | % | ||||
| TLR-3_ 7C/A | AA | 0 | 0.0 | 2 | 5.7 | 0.99 | NA |
| AC | 17 | 26.2 | 7 | 20.0 | 0.59 | 0.76 (0.27–2.06) | |
| CC | 48 | 73.8 | 26 | 74.3 | Reference | ||
| AA + AC | 17 | 26.2 | 9 | 25.7 | 0.962 | 0.97 (0.38–2.49) | |
| Allele A | 17 | 13 | 11 | 16 | 0.608 | 1.23 (0.54–2.81) | |
| Allele C | 113 | 87 | 59 | 84 | Reference | ||
| TLR-3-1377 C/T | TT | 4 | 6.2 | 2 | 5.7 | 0.562 | 1.70 (0.28–10.20) |
| CT | 10 | 15.4 | 18 | 51.4 | < 0.001 | 6.12 (2.33–16.04) | |
| CC | 51 | 78.5 | 15 | 42.9 | Reference | ||
| TT + CT | 14 | 21.5 | 20 | 57.1 | < 0.001 | 4.85 (1.98–11.86) | |
| Allele T | 18 | 14 | 22 | 31.4 | 0.003 | 2.85 (1.40–5.79) | |
| Allele C | 112 | 86 | 48 | 68.6 | Reference | ||
| TLR-9 1237T/C | CC | 1 | 1.5 | 2 | 5.7 | 0.22 | 4.5 (0.38–52.05) |
| TC | 10 | 15.4 | 9 | 25.7 | 0.17 | 2.02 (0.73–5.62) | |
| TT | 54 | 83.1 | 24 | 68.6 | Reference | ||
| CC + TC | 11 | 16.9 | 11 | 31.4 | 0.095 | 2.25 (0.85–5.90) | |
| Allele C | 12 | 9 | 13 | 18.6 | 0.057 | 2.24 (0.96–5.22) | |
| Allele T | 118 | 91 | 57 | 81.4 | Reference | ||
CI = confidence interval; OR = odds ratio. P value < 0.05 is considered significant.