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PRKCD-AKT-MTOR-ULK1 signaling pathway for autophagy suppression in cisplatin nephrotoxicity. Upon cisplatin treatment, PRKCD is phosphorylated and activated by SRC family kinases and AKT is phosphorylated at Thr308 by PDPK1, promoting PRKCD binding and phosphorylation of AKT at Ser473 and full activation of AKT. AKT then activate MTOR to repress ULK1 and associated autophagy, leading to apoptosis.
