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A schematic model depicting the hypothetical role of ERK5 (red bars) in the cellular response to unrepaired DNA damage in VDJ recombination in thymocytes. NHEJ, non-homologous end-joining pathway of DSB repair. HR, homologous recombination. gH2AX, phosphorylated H2AX. ATM-RAG, indicates the cooperation between both proteins to stabilize the DSB. The bars indicate inhibitory function.
