Table 1. Phospholipids and fatty acyl composition in mitochondria from wild-type mice [SkQ1-treated (WT+SkQ1) or non-treated (WT)] and mtDNA mutator mice [SkQ1-treated (Mut+SkQ1) or non-treated (Mut)].
| Mitochondria from tissue | Phospholipid and their fatty acyls (FA) | WT | WT+SkQ1 | Mut | Mut+SkQ1 |
|---|---|---|---|---|---|
| Skeletal muscle | Phosphatidylcholine | 51.0±3.6 | 50.0±2.8 | 52.0±4.2 | 52.0±3.1 |
| Phosphatidylethanolamine | 19±2 | 18±1 | 22±2 | 19±2 | |
| Cardiolipin | 17±1 | 20±2 | 13±1# | 18±1* | |
| Phosphatidylinositol | 5.0±0.7 | 4.0±0.6 | 5.0±0.6 | 4.0±0.4 | |
| Phosphatidylserine | 5.0±1.1 | 5.0±0.9 | 4.0±0.8 | 4.0±0.7 | |
| Phosphatidic acid | 3.0±0.6 | 3.0±0.2 | 4.0±0.4 | 3.0±0.3 | |
| Saturated FA | 20±1 | 20±2 | 31±2# | 23±1* | |
| Monounsaturated FA | 22±2 | 20±1 | 21±1 | 22±0 | |
| Polyunsaturated FA n-3 | 22±1 | 24±1 | 24±1 | 22±1 | |
| Polyunsaturated FA n-6 | 37±3 | 37±1 | 24±1# | 33±1* | |
| Liver | Phosphatidylcholine | 45.5±4.2 | 44.2±2.6 | 47±3 | 44.5±3.8 |
| Phosphatidylethanolamine | 34±2 | 32±2 | 35±2 | 33±3 | |
| Cardiolipin | 15±2 | 20±2* | 12±1 | 18±1* | |
| Phosphatidylinositol | 5.0±1.1 | 3.0±1.0 | 5.0±0.7 | 4.0±0.9 | |
| Phosphatidylserine | 0.5±0.2 | 0.8±0.2 | 1.0±0.5 | 0.5±0.1 | |
| Saturated FA | 19±1 | 21±1 | 29±2# | 22±2* | |
| Monounsaturated FA | 24±1 | 22±1 | 22±1 | 23±1 | |
| Polyunsaturated FA n-3 | 21±1 | 23±2 | 26±2 | 24±1 | |
| Polyunsaturated FA n-6 | 36±2 | 35±2 | 23±2# | 32±1* |
The values are expressed in mol % and represent the means ± S.E. of 6 independent mitochondrial preparations isolated in parallel from 4 groups of mice, 252–259 days old.
*
indicates statistical difference between SkQ1-treated and non-treated mice (p < 0.05).
#
indicates statistical difference between wild-type and mtDNA mutator mice (p < 0.05).