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. 2017 Feb 6;9(2):447–463. doi: 10.18632/aging.101170

Figure 5. Models of aging-related changes in TCA cycle and pyrimidine metabolism.

Figure 5

Figure 5

(A) A summary of the biochemical pathway of TCA cycle metabolism alerted during aging, and glp-1 against WT. In summary, with aging, accumulation of the TCA cycle intermediates such as citrate and malate suggests increased TCA cycle metabolism. Furthermore, in the long-lived glp-1 mutants, the levels of TCA cycle intermediates decreased at stage of the young adults and 10-day adults compared with WT.