Table 3. The associations between the MT-2A rs10636 polymorphism and clinical characteristics of BC patients.
| Variables | GG(%) | GC(%) | p | OR(95%CI) | CC(%) | p | OR(95%CI) | GC+CC (%) | p | OR(95%CI) |
|---|---|---|---|---|---|---|---|---|---|---|
| Tumor size | ||||||||||
| <2CM | 57(37.5) | 54(35.5) | 41(27) | 95(62.5) | ||||||
| ≥2CM | 98(31.9) | 104(33.9) | 0.63 | 1.12(0.71-1.78) | 105(34.2) | 0.11 | 1.49(0.92-2.42) | 209(68.1) | 0.23 | 1.2(0.85-1.92) |
| LN metastasis | ||||||||||
| Negative | 64(34.8) | 65(35.3) | 55(30) | 120(65.2) | ||||||
| Positive | 84(30.5) | 103(37.5) | 0.41 | 1.2(0.77-1.89) | 88(32) | 0.41 | 1.22(0.76-1.95) | 191(69.5) | 0.34 | 1.2(0.82-1.8 |
| ER | ||||||||||
| Negative | 77(38.1) | 63(31.2) | 62(30.7) | 125(61.9) | ||||||
| Positive | 79(30.4) | 91(35.4) | 0.135 | 1.41(0.9-2.21) | 87(33.9) | 0.174 | 1.3(0.87-2.15) | 178(69.3) | 0.1 | 1.3(0.94-2.05) |
| PR | ||||||||||
| Negative | 90(43.3) | 96(46.2) | 22(10.5) | 118(56.7) | ||||||
| Positive | 111(44.2) | 106(42.2) | 0.58 | 0.90(0.61-1.33) | 34(13.5) | 0.46 | 1.25(0.69-2.29) | 140(55.8) | 0.84 | 0.96(0.66-1.39) |
| Her-2 | ||||||||||
| Negative | 100(30.3) | 112(33.9) | 118(35.8) | 230(69.7) | ||||||
| Positive | 47(36.4) | 44(34.1) | 0.48 | 0.84(0.51-1.37) | 38(29.5) | 0.14 | 0.69(0.41-1.13) | 82(63.6) | 0.21 | 0.76(0.49-1.16) |
| Ki-67 | ||||||||||
| <50% | 80(27.2) | 85(28.9) | 129(43.9) | 214(72.8) | ||||||
| ≥50% | 42(25.5) | 47(28.5) | 0.84 | 1.05 (0.63-1.77 ) | 76(46.1) | 0.63 | 1.12 (0.7-1.79 ) | 123(74.5) | 0.68 | 1.1 (0.71-1.69 ) |
| Histological grade | ||||||||||
| SBR 1-2 | 65(26.6) | 85(34.8) | 94(38.5) | 179(73.4) | ||||||
| SBR 3 | 79(36.7) | 83(38.6) | 0.34 | 0.8 (0.51-1.26 ) | 53(24.6) | 0.001 | 0.46 (0.29-0.74 ) | 136(63.3) | 0.02 | 0.63 (0.42-0.93 ) |
| Venous Invasion | ||||||||||
| Non-little | 34(11.6) | 64(21.9) | 194(66.4) | 258(88.4) | ||||||
| Moderate-severe | 24(14.4) | 65(38.9) | 0.25 | 1.44 (0.77-2.69 ) | 78(46.7) | 0.06 | 0.57 (0.32-1.02 ) | 143(85.6) | 0.4 | 0.79 (0.45-1.38 ) |
LN: Axillary lymph node; ER: Estrogen receptor; PR: Progesterone receptor; Her-2: human epidermal growth factor receptor 2; SBR: Scarff, Bloom and Richardson tumor grade