Table 1.

Dose prescription

Target volume	Dose (fraction dose) (Gy)		aEQD2 (Gy)
	Intervention-arm	Control-arm
PTVGBTV-high-risk	66 (2.00)	66 (2.00)	≈ 73
PTVCTV-high-risk	62 (1.88)	62 (1.88)	≈ 67
PTVintermediate-risk	58 (1.76)	-	≈ 60
PTVlow-risk	42 (1.27)	48 (1.45)	≈ 35 vs. 45

^aThe equivalent dose in 2 Gy fractions (EQD2) was calculated using the linear-quadratic model using an α/β = 10 Gy for tumor [34]. Differences in treatment time were taken into account by a correction of 0.6 Gy per day to compensate for tumor repopulation [35]

An accelerated fractionation schedule will be used, 33 fractions in 5 weeks (33 days)