Fig. 1.

Intracranial inoculation of SLEV BeH 355964 causes disease and mortality in adult wild-type mice in an inoculum-dependent manner. a Eight- to 12-week-old BALB/c mice were inoculated intracranially (i.c.) or intraperitoneally (i.p.) with 10⁵ PFU of SLEV BeH 355964 and observed for 14 days post infection (p.i.). b, c, d Eight- to 12-week-old BALB/c (b), SV129 (c), and C57BL/6 (d) were infected i.c. with different inocula of SLEV BeH 355964 and observed for 14 days p.i.. Results are expressed as percentage of survival in each group and are representative of two experiments. Mock = injected with saline. N = 6–9 mice. ***P < 0.001 compared to the respective Mock-infected group